Psychogenic death among shamans and sorcerers: when symbols become symptoms, and fear becomes a sentence.
A man dies. No one touched him.
He was sitting in the shade, his face pale, his eyes wide open. His breathing slowed, his heart rate dropped below the safety threshold. No visible wounds, no poison in his blood. Someone had spoken his name during a ritual. Someone had cursed him.
A few days later, he died.
In Africa, they call it Voodoo. In Italy, for centuries, they have spoken of spells. And those who practice them are still called, with a hint of fear or derision, witches. The name changes, but not the mechanism: the psychological effect of a ritual condemnation can become biologically lethal.
The question then arises: can a mental belief really cause death? Science is beginning to answer: yes. And the way it happens is surprising.
Cortical freezing: the biology of mental paralysis
It’s not just about fear. Freezing is not panic, but a real functional interruption of certain areas of the brain. In situations of extreme stress, the brain can activate an ancient defensive mechanism: tonic immobility.
This response is mediated by the dorsal vagus nerve, which, in critical conditions, shuts down sympathetic responses and slows down vital functions. The prefrontal cortex, amygdala, and parasympathetic system work together to produce a neurophysiological state similar to dissociation.
Stephen Porges’ polyvagal theory explains how our nervous system can literally shut down when faced with a threat that is perceived as unavoidable.

Nocebo and symbolic power: the poison of words
The nocebo effect is the most concrete example of how a belief can cause real damage: pain, nausea, paralysis. All it takes is the wrong word, a gesture laden with meaning.
In a ritual context, these dynamics are amplified. Italian popular culture, like many others, has built a network of symbols, fears, and defenses around this mechanism. Curses, often entrusted to witches, are verbal or gestural curses that bring bad luck, illness, and ruin. Those who believe in their power immediately feel the effects: anxiety, insomnia, loss of appetite, and pain without cause.
As in Voodoo, what matters is not objective reality, but the shared power of belief. And the body, immersed in a strong symbolic context, reacts as if that gesture were truly deadly.
Clinic of psychogenic death: from the announcement to death
Here, in summary, is the pathophysiological sequence that can lead to so-called “Voodoo death,” or in broader terms, death by symbolic condemnation:
Pronouncement of the curse: verbal, ritual, or gestural, by an authoritative figure (shaman or witch).
Psychosomatic activation: the individual, convinced of the power of the curse, goes into shock. Acute release of adrenaline and cortisol.
Neurochemical collapse:
– rapid depletion of catecholamines
– drastic drop in serotonin
– paradoxical effect of tryptophan
Deep biological depression: loss of muscle tone, anhedonia, withdrawal.
Slowing of vital functions:
– bradycardia and bradypnea
– reduction in blood pressure
– progressive cerebral hypoxia
Vascular epistasis: first arterial, then atrial. The heart becomes fatigued.
Catatonia and pre-comatose state
Cardiac collapse: due to cerebral hypoperfusion and prolonged neurovegetative imbalance. This sequence was described by Walter Cannon in his early studies on “ritual deaths,” explored in depth by Claude Lévi-Strauss in a symbolic context, and recognized in its biological plausibility by Robert Sapolsky, who studied the effects of chronic stress and deep beliefs on the central nervous system.
Voodoo and spells: a shared cultural code
We are more similar than we think. If in Voodoo the figure of the shaman is central, in our countryside it was the witch, the old woman who “removed the evil eye” or who, if offended, “bound the soul.”
The words change, but the human brain responds to beliefs, not to objective truth.
Cultural beliefs shape our nervous system. Words have synaptic weight. Rituals, even if they have no objective basis, trigger profound physiological responses. And neuroplasticity, combined with epigenetics, creates fertile ground for the effect of what we believe to be real.
Conclusion: the power of belief must be understood, not mocked
Death by Voodoo, or by a spell, is not a folkloric phenomenon to be dismissed with condescension. It is a dramatic and real example of how mind, body, and culture are intertwined.
When science opens itself to listening to myth, it discovers that not everything symbolic is harmless. And that beliefs, if shared and deeply rooted, can profoundly alter biology.
Understanding these mechanisms means revolutionizing medicine, psychiatry, and psychotraumatology. It means treating even what cannot be seen, but which affects the heartbeat, consciousness, and life itself.





